Archive for the ‘lithium’ Category

Treament for a Tiny Brain

Posted: October 2, 2012 in brain matter, lithium, nf

Treatment for Manic-Depressive Illness Restores Brain Volume Deficits

ScienceDaily (Feb. 17, 2011) — Lithium, introduced in the late 1940’s, was the first “wonder drug” in psychiatry. It was the first medication treatment for the manic and depressive episodes of bipolar disorder and it remains among one of the most effective treatments for this disorder.

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In the past 15 years, as molecular mechanisms underlying the treatment of bipolar disorder began to emerge, basic research studies conducted in animals began to identify neuroprotective and perhaps neurotrophic effects of this important medication.
The identification of these molecular actions of lithium coincided with the discovery of regional brain volume deficits in imaging studies of people with bipolar disorder. In particular, a generation of research studies identified alterations, predominately reductions, in the size of brain regions involved in mood regulation. These studies also began to provide hints that some of the treatments for bipolar disorder would increase the volumes of these brain regions.
In a massive research effort published in Biological Psychiatry, eleven international research groups collaborated to pool brain imaging data from adults with bipolar disorder. This allowed them to perform a mega-analysis to evaluate the differences in brain structure between individuals with bipolar disorder and healthy comparison subjects.
They found that individuals with bipolar disorder had increased right lateral ventricular, left temporal lobe, and right putamen volumes. Individuals with bipolar disorder who were not taking lithium had a reduction in cerebral and hippocampal volumes compared with healthy comparison subjects. Importantly, however, bipolar patients taking lithium displayed significantly increased hippocampal and amygdala volume compared with patients not treated with lithium and healthy comparison subjects. Cerebral volume reduction was also significantly associated with illness duration in bipolar individuals.
“This important mega-analysis provides strong support for regional brain structural alterations associated with bipolar disorder, but also sends a signal of hope that treatments for this disorder may reduce some of these deficits,” commented Dr. John Krystal, Editor of Biological Psychiatry.

note, all funny pix associated with these articles are in fun and not from original articles.

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ScienceDaily: Bipolar Disorder News

Possible mechanism identified for how lithium treats bipolar disorder
Lithium has been established for more than 50 years as one of the most effective treatments for manic depression, clinically termed bipolar disorder. However, scientists have never been entirely sure exactly why it is beneficial. Now, new research suggests a possible mechanism for why lithium works, opening the door for better understanding of the illness and potentially more effective treatments.
About.com Bipolar Disorder: Most Popular Articles

Lithium Toxicity – Types, Causes and Treatment
When someone takes too much lithium, a medication most often used as a mood stabilizer for bipolar disorder, lithium toxicity can be the result. The result can be mild, moderate or severe, depending on the amount ingested, how long ago, and whether the patient was already taking lithium regularly. The three types of lithium toxicity are acute, chronic, and acute on chronic. This article describes each type, the possible symptoms, and the various treatments.

Lithium History / How It Works

Posted: September 25, 2012 in lithium, nf
About.com Bipolar Disorder: Most Popular Articles

Lithium History / How It Works
The discovery that Lithium was a mood stabilizer for manic depression came 50 years before scientists unlocked the secret to how it works. For the last several decades, Lithium has been one of the most common medications prescribed for bipolar disorder.